発表論文

2024

Datta A, Istiaq A, Tamura S, Ohta K. (2024). Bacterial Ribosomes Induce Plasticity in Mouse Adult Fibroblasts. Cells 13(13):1116. (doi:10.3390/cells13131116)

2023

太田訓正. (2023). リボソームによる細胞の形質転換. 月刊細胞 THE CELL. 55(6):29-32.

Panawan O, Silsirivanit A, Chang C, Putthisen S, Boonnate P, Yokota T, Nishisyama-Ikeda Y, Detarya M, Sawanyawisuth K, Kaewkong W, Muisuk K, Luang S, Vaeteewoottacharn K, Kariya R, Yano H, Komohara Y, Ohta K, Okada S, Wongkham S, Araki N. (2023). Establishment and characterization of a novel cancer stem-like cell of cholangiocarcinoma. Cancer Science, 114(8), 3230. (doi:10.1111/cas.15812)

2022

太田訓正. (2022). プロテオグリカンTsukushiによる脳神経幹細胞ニッチの制御. 医学のあゆみ. 280(3):234-235.

Istiaq A, Umemoto T, Ito N, Suda T, Shimamura K, Ohta K. Tsukushi proteoglycan maintains RNA splicing and developmental signaling network in GFAP-expressing subventricular zone neural stem/progenitor cells. Front Cell Dev Biol. 2022;10:994588. Published 2022 Nov 21. (doi:10.3389/fcell.2022.994588)

Quaresima S, Istiaq A, Jono H, Cacci E, Ohta K, Lupo G. Assessing the Role of Ependymal and Vascular Cells as Sources of Extracellular Cues Regulating the Mouse Ventricular-Subventricular Zone Neurogenic Niche. Front Cell Dev Biol. 2022;10:845567. Published 2022 Apr 5. (doi:10.3389/fcell.2022.845567)

Istiaq A, Ohta K. A review on Tsukushi: mammalian development, disorders, and therapy [published online ahead of print, 2022 Mar 1]. J Cell Commun Signal. 2022;10.1007/s12079-022-00669-z. (doi:10.1007/s12079-022-00669-z)

Putthisen, S., Silsirivanit, A., Panawan, O., Niibori-Nambu, A., Nishiyama-Ikeda, Y., Ma-In, P., Luang, S., Ohta, K., Muisuk, K., Wongkham, S., & Araki, N. (2022). Targeting alpha2,3-sialylated glycan in glioma stem-like cells by Maackia amurensis lectin-II: A promising strategy for glioma treatment. Experimental cell research, 410(1), 112949. (https://doi.org/10.1016/j.yexcr.2021.112949)

2021

Shirakawa, Y., Ohta, K., Miyake, S., Kanemaru, A., Kuwano, A., Yonemaru, K., Uchino, S., Yamaoka, M., Ito, Y., Ito, N., Hide, T., Shinojima, N., Mukasa, A., Saito, H., & Jono, H. (2021). Glioma Cells Acquire Stem-like Characters by Extrinsic Ribosome Stimuli. Cells, 10(11), 2970. (https://doi.org/10.3390/cells10112970)

Istiaq, A.; Ohta, K. (2021) Ribosome-Induced Cellular Multipotency, an Emerging Avenue in Cell Fate Reversal. Cells, 10, 2276. (https://www.mdpi.com/2073-4409/10/9/2276)

Kudo, M., & Ohta, K. (2021). Regulation of the Brain Neural Niche by Soluble Molecule Akhirin. Journal of Developmental Biology, 9(3), 29. (https://www.mdpi.com/2221-3759/9/3/29)

Miwa, T., Ito, N., & Ohta, K. (2021). Tsukushi is essential for the formation of the posterior semicircular canal that detects gait performance. Journal of Cell Communication and Signaling, 10.1007/s12079-021-00627-1. Advance online publication. (https://link.springer.com/article/10.1007%2Fs12079-021-00627-1)

Ito, N., Riyadh, M. A., Ahmad, S., Hattori, S., Kanemura, Y., Kiyonari, H., Abe, T., Furuta, Y., Shinmyo, Y., Kaneko, N., Hirota, Y., Lupo, G., Hatakeyama, J., Abdulhaleem M, F. A., Anam, M. B., Yamaguchi, M., Takeo, T., Takebayashi, H., Takebayashi, M., Oike, Y., … Ohta, K. (2021). Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. Science Translational Medicine, 13(587), eaay7896. (https://www.science.org/doi/10.1126/scitranslmed.aay7896)

Istiaq, A., Ishtiyaq Ahmad, S. A., Anam, M. B., Kudo, M., Nakayama, S., Ito, N., & Ohta, K. (2021). Chapter 9—Bacteria to form induced pluripotent stem cells. In A. Birbrair (Ed.), Methods in iPSC Technology (Vol. 9, pp. 231–247). Academic Press. (https://www.sciencedirect.com/science/article/pii/B9780323857666000139?via%3Dihub)

Kudo, M., Anam, M. B., Istiaq, A., Ahmad, S., Ito, N., & Ohta, K. (2021). Ribosome Incorporation Induces EMT-like Phenomenon with Cell Cycle Arrest in Human Breast Cancer Cell. Cells, Tissues, Organs, 1–10. Advance online publication. (https://doi.org/10.1159/000513908)

Anam, M. B., Istiaq, A., Kariya, R., Kudo, M., Ishtiyaq Ahmad, S. A., Ito, N., Okada, S., & Ohta, K. (2021). Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines. Biochemistry and Biophysics Reports, 26, 100946. (https://doi.org/10.1016/j.bbrep.2021.100946)

2020

Shirakawa Y, Hide T, Yamaoka M, et al. Ribosomal protein S6 promotes stem-like characters in glioma cells. Cancer Sci. 2020;111(6):2041-2051. (https://onlinelibrary.wiley.com/doi/full/10.1111/cas.14399)

Miwa T, Ohta K, Ito N, et al. Tsukushi is essential for the development of the inner ear. Mol Brain. 2020;13(1):29.(https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-020-00570-z)

Shah A., I.,A., Mohammad B., A., Arif I., Ito N., and Ohta K.(2020) Tsukushi is essential for proper maintenance and terminal differentiation of mouse hippocampal neural stem cells. Development, Growth & Differentiation. (https://onlinelibrary.wiley.com/doi/full/10.1111/dgd.12649)

Mohammad B., A., Shah A., I., A., Kudo M., Arif I., Abdulhaleem M. F. A., Ito N., and Ohta K.(2020) Akhirin affects neurogenesis at both subventricular zone and hippocampal neurogenic niches. Development, Growth & Differentiation. (https://onlinelibrary.wiley.com/doi/full/10.1111/dgd.12646 )

2019

工藤三希子、伊藤尚文、河野利恵、太田訓正 (2019) 毛周期におけるTsukushiとTGF – βシグナル. 毛髪科学の新展開　監修：岩渕徳郎 シーエムシー出版 (P16-24). (http://www.cmcbooks.co.jp/products/detail.php?product_id=5684 )

Yamada T., Ohta K., Motooka Y., Fujino K., Kudoh S., Tenjin Y., Sato Y., Matsuo A., Ikeda K., Suzuki M., Ito T.(2019) Significance of Tsukushi in lung cancer. Lung Cancer. (https://www.ncbi.nlm.nih.gov/pubmed/31027686 )

Ohta K., Aoyama E., Shah A., I., A., Ito N., Mohammad B., A., Kubota S. and Takigawa M.(2019). CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi. Journal of Cell Communication and Signaling. (https://www.ncbi.nlm.nih.gov/pubmed/30232710 )

Wang, Q., Sharma, V.P., Shen, H., Xiao, Y., Zhu, Q., Xiong, X., Guo, L., Jiang, L., Ohta, K., Li, S., Shi, H., Rui, L., and Lin, J.D.(2019). The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation. Nature Metabolism. (https://www.nature.com/articles/s42255-018-0020-9 )

2018

Ito N., Mohammad B., A., Shah A., I., A., and Ohta K.(2018) Transdifferentiation of human somatic cells by ribosome. Development Growth and Differentiation.(https://www.ncbi.nlm.nih.gov/pubmed/29845598)

Ito N., Katoh K., Kushige H., Saito Y., Umemoto T., Matsuzaki Y., Kiyonari H., Kobayashi D., Soga M., Era T., Araki N., Furuta Y., Suda T., Kida Y, and Ohta K.(2018) Ribosome incorporation into somatic cells promotes transdifferentiation towards multipotency. Scientific Reports. (https://www.ncbi.nlm.nih.gov/pubmed/29374279)

Ito N., and Ohta K.(2018) Reprogramming of sells by Lactic Acid Bacteria. Applied RNA Biosciences. (Eds. Matsuda S. and Izawa S.) https://link.springer.com/chapter/10.1007%2F978-981-10-8372-3_4)

Ito N., and Ohta K.(2018) 乳酸菌による細胞リプログラミング. 酵母菌・麹菌・乳酸菌の産業応用展開」監修　五味勝也・阿部敬悦.
シーエムシー出版 (P251-258)

Shah A., I., A., Mohammad B., A., Ito N., and Ohta K.(2018) Involvement of Tsukushi in diverse
developmental processes. Journal of Cell Communication and Signaling. (https://www.ncbi.nlm.nih.gov/pubmed/29352451)

2017

Kawano R., Ohta K., and Lupo, G.(2017) Cadherin-7 enhances Sonic Hedgehog signaling by preventing Gli3 repressor formation during neural tube patterning. Open Biology. (https://rsob.royalsocietypublishing.org/content/7/12)

Yano K., Washio K., Tsumanuma U., Yamato M., Ohta K., Okano T., and Izumi Y.(2017) The role of Tsukushi (TSK), a small leucine-rich repeat proteoglycan, in bone growth. Regenerative Therapy. (https://www.sciencedirect.com/science/article/pii/S2352320417300263)

Md. Safiqul I., Fan-Yan Wei, Ohta K., Shigematsu N., Fukuda T., Tomizawa K., Yoshizawa T., and Yamagata K.(2017) Sirtuin 7 is involved in the consolidation of fear memory in mice. Biochem Biophys Res Commun. (https://www.ncbi.nlm.nih.gov/pubmed/29101029)

2016

Uzzal Kumar A., Abdulhaleem M. F. A., Riyadh A., and Ohta K. (2016). Regulation of the neural niche by the soluble molecule Akhirin. Development Growth and
Differentiation. 58(5):463-8. (https://www.ncbi.nlm.nih.gov/pubmed/27134067)

2015

Shinmyo Y.#, Riyadh M.A.#, Giasuddin A., Iftekhar Bin N., Mahmud H., Takebayashi H., Kawasaki H., Ohta K., and Tanaka H. (2015). Draxin from neocortical neurons controls the guidance of thalamocorticalprojections into the neocortex. Nature Communications. 6:10232. (http://www.ncbi.nlm.nih.gov/pubmed/26659141)

Acharjee U.K., Gejima R., Abdulhaleem M. F. A., Riyadh M.A., Tanaka H., Ohta K.(2015). Tsukushi expression is dependent on Notch signaling and oscillated in the presomitic mesoderm during chick somitogenesis. Biochem. Biophys. Res. Commun. 465(3):625-30. (http://www.ncbi.nlm.nih.gov/pubmed/26299926)

Ito N., Ohta K.(2015). Reprogramming of human somatic cells by bacteria. Dev. Growth. Differ. 57(4):305-12. (http://www.ncbi.nlm.nih.gov/pubmed/25866152)

Abdulhaleem M. F. A., Song X., Kawano R., Uezono N., Ito .A, Ahmed G., Hossain M., Nakashima .K, Tanaka H., Ohta K. (2015). Akhirin regulates the proliferation and
differentiation of neural stem cells in intact and injured mouse spinal cord. Dev. Neurobiol. 75(5): 494-504. (http://www.ncbi.nlm.nih.gov/pubmed/25331329)

太田　訓正.(2015). ギルバート発生生物学　(Developmental Biology, tenth edition) メディカル・サイエンス・インターナショナル翻訳出版 Scott. Gilebert著, 監修　阿形清和・高橋淑子, Part2導入部・Glossary担当 , 2015.03.20発行

2014

Niimori D., Kawano R., Niimori-Kita K., Ihn H., Ohta K.(2014). Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors. J.Cell Communication and Signaling.8(3):173-7. (http://www.ncbi.nlm.nih.gov/pubmed/25159578)

太田　訓正. (2014). 乳酸菌を用いた多能性細胞の創造.日本乳酸菌学会誌.No.1(Vo.25): P13-17.

Kunimasa Ohta.(2014).Hisato Kondo・AtsushiKuroiwa Editors The Role of Tsukushi as an Extracellular Signaling Coordinator. New Principles
in Developmantal Processes. (Springer) Chapter17. P227 – 238. (http://link.springer.com/chapter/10.1007/978-4-431-54634-4_17)

Riyadh M.A., Shinmyo Y., Ohta K., Tanaka H.(2014). Inhibitory effects of draxin on axonal outgrowth and migration of precerebellar neurons. Biochem. Biophys. Res. Commun.449(1):161-74. (http://www.ncbi.nlm.nih.gov/pubmed/24832731)

Song X., Tanaka H., Ohta K.(2014). Multiple roles of Equarin during lens development. Dev. Growth. Differ. 56(3):199-205. (http://www.ncbi.nlm.nih.gov/pubmed/24673466)

2013

Ninomiya S., Esumi S., Ohta K., Fukuda T., Ito N., Imayoshi I., Kageyama R., Ikeda T., Itohara S., Tamamaki N. (2013). Amygdala
kindling induces nestin expression in the leptomeninges of the neocortex. Neurosci. Resl. 75(2):121-129. (http://www.ncbi.nlm.nih.gov/pubmed/23305954)

Hossain M., Ahmed G., Naser I.B., Shinmyo Y., Ito N., Riyadh M.A., Felembam A., Song X., Ohta K., Tanaka H. (2013). The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation. Dev. Biol. 374(1):58-70. (http://www.ncbi.nlm.nih.gov/pubmed/23206892)

Song X., Sato Y., Sekiguchi K., Tanaka H., Ohta K. (2013). Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development. Dev. Dyn. 2013. 242(1):23-29. (http://www.ncbi.nlm.nih.gov/pubmed/23161803)

2012

Ohta K., Kawano R., Ito N. (2012). Lactic acid bacteria convert human fibroblasts to multipotent cells. PLOS ONE. 7(12):e51866. (http://www.ncbi.nlm.nih.gov/pubmed/23300571)

Niimori D., Kawano R., Felemban A., Niimori-Kita K., Tanaka H., Ihn H., Ohta K. (2012). Tsukushi controls the hair cycle by regulating TGF-β1 signaling. Dev. Biol. 372(1):81-87. (http://www.ncbi.nlm.nih.gov/pubmed/22995554)

Song X., Sato Y., Felemban A., Ito N., Hossain M., Ochiai H., Yamamoto T., Sekiguchi K., Tanaka H., Ohta K. (2012). Equarin is involved as an FGF signaling modulator in chick lens differentiation. Dev. Biol. 368(1):109-117. (http://www.ncbi.nlm.nih.gov/pubmed/22659080)

2011

Ohta K., Ito N., Kuriyama S., Lupo G., Nakayama R., Oshima N., Kosaka M., Ohnuma S., Nakagawa S., Tanaka, H. (2011). Tsukushi is a Frizzled4 Ligand that, in Competition with Wnt2b, Regulates Retinal Stem/Progenitor Cell Proliferation in Adult Mammalian Eye. Proc. Natl. Acad. Sci. U S A. 108, 14962-14967. (http://www.ncbi.nlm.nih.gov/pubmed/21856951)

Ahmed G., Shinmyo Y., Ohta K., Islam S.M., Hossain M., Naser I.B., Riyadh M.A., Su Y., Zhang S., Tessier-Lavigne M. , Tanaka H. (2011). Draxin Inhibits Axonal Outgrowth through the Netrin Receptor DCC. J. Neurosci. 31, 14018 -14023. (http://www.ncbi.nlm.nih.gov/pubmed/21957262)

2010

太田　訓正. (2010). 脳神経幹細胞の未分化性維持機構. ブレインサイエンス・レビュー 2010. p81-94.

Ito A., Shinmyo Y., Abe T., Oshima N., Tanaka H., Ohta K. (2010). Tsukushi is required for anterior commissure formation in mouse brain. Biochem. Biophys. Res. Commun. 402, 813-818. (http://www.ncbi.nlm.nih.gov/pubmed/21055390)

Ahmed G., Shinmyo Y., Naser I.B., Hossain M., Song X., Tanaka H. (2010). Olfactory bulb axonal outgrowth is inhibited by draxin. Biochem. Biophys. Res. Commun. 398, 730-734. (http://www.ncbi.nlm.nih.gov/pubmed/20621059)

Su Y., Zhang S., Islam S. M., Shinmyo Y., Naser I. B., Ahmed G., Tanaka H. (2010). Draxin is involved in the proper development of the dI3 interneuron in chick spinal cord. Dev. Dyn. 239, 1654- 1663. (http://www.ncbi.nlm.nih.gov/pubmed/20503362)

Zhang S., Su Y., Shinmyo Y., Islam S. M., Naser I. B., Ahmed G., Tamamaki N., Tanaka H. (2010). Draxin, a repulsive axon guidance protein, is involved in hippocampal development. Neurosci. Res. 66, 53- 1. (http://www.ncbi.nlm.nih.gov/pubmed/19808066)

Uejima A., Amano T., Nomura N., Noro M., Yasue T., Shiroishi T., Ohta K.,Yokoyama H., Tamura K. (2010). Anterior shift in gene expression precedes anteriormost digit formation in amniote limbs Neuroreport. Dev. Growth. Differ.52(2):223-234. (http://www.ncbi.nlm.nih.gov/pubmed/20100248)

Hayashida M., Minod R., Shinmyo Y., Ohta K., Tanaka H., Yumoto E. (2010). PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neurons. Neuroreport.21(2):90-93. (http://www.ncbi.nlm.nih.gov/pubmed/1999703.(https://www.sciencedirect.com/science/article/pii/S2352320417300263