{"id":5,"date":"2018-11-27T09:17:08","date_gmt":"2018-11-27T09:17:08","guid":{"rendered":"http:\/\/kyushu-stemcellbiology.com\/about\/"},"modified":"2020-09-08T04:07:41","modified_gmt":"2020-09-08T04:07:41","slug":"research-projects","status":"publish","type":"page","link":"https:\/\/kyushu-stemcellbiology.com\/ja\/research-projects\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"5\" class=\"elementor elementor-5\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d7d8b56 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d7d8b56\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fd69444\" data-id=\"fd69444\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-abcc2f2 elementor-widget elementor-widget-heading\" data-id=\"abcc2f2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">\u7814\u7a76\u5185\u5bb9<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7e036a1 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7e036a1\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ab09437\" data-id=\"ab09437\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b980c8d elementor-widget elementor-widget-spacer\" data-id=\"b980c8d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c40d7b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5c40d7b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2ebbf9c\" data-id=\"2ebbf9c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fe195c7 elementor-widget elementor-widget-heading\" data-id=\"fe195c7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Ribosome<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc051dd elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"dc051dd\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;none&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 24 24&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M24,8v12H0V8H24z M24,4v1H0V4H24z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e5f497e elementor-widget elementor-widget-text-editor\" data-id=\"e5f497e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"margin-bottom: 1em; padding: 5px; font-family: \u7e5d\uff61\u7e67\uff64\u7e5d\uff6a\u7e67\uff6a, Meiryo, '\ufffd\uff6d\ufffd\uff73 \ufffd\uff70\u7e67\uff74\u7e67\uff77\u7e5d\ufffd\u3051', 'Hiragino kaku Gothic Pro', '\u7e5d\u5075\u039b\u7e67\uff6e\u7e5d\u624b\uff67\u5075\u3056 Pro W3', Osaka, sans-serif; font-size: small; font-weight: 400; line-height: 1.4em; line-break: strict; color: #333333; text-shadow: #ffffff 0px 1px 0px; font-style: normal;\">\u4e73\u9178\u83cc\u306f\u30d2\u30c8\u306e\u5065\u5eb7\u3092\u4fc3\u9032\u3059\u308b\u6709\u540d\u306a\u7d30\u83cc\u306e\u4e00\u3064\u3067\u3059\u3002\u4e73\u9178\u83cc\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u8178\u5185\u74b0\u5883\u304c\u6574\u3044\u3001\u514d\u75ab\u529b\u304c\u30a2\u30c3\u30d7\u3001\u7f8e\u5bb9\u52b9\u679c\u3082\u3042\u308b\u3001\u3068\u826f\u3044\u3053\u3068\u304c\u591a\u304f\u6319\u3052\u3089\u308c\u307e\u3059\u304c\u3001\u4e73\u9178\u83cc\uff08LAB)\u304c\u8178\u4e0a\u76ae\u7d30\u80de\u306e\u30a8\u30d4\u30b2\u30ce\u30e0\u3084\u7d30\u80de\u6a5f\u80fd\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306a\u3069\u306e\u57fa\u672c\u7684\u306a\u3053\u3068\u306f\u3001\u307b\u3068\u3093\u3069\u7814\u7a76\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u591a\u304f\u306e\u3053\u3068\u304c\u8aac\u660e\u3067\u304d\u306a\u3044\u307e\u307e\u52b9\u679c\u3060\u3051\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin-bottom: 1em; padding: 5px; font-family: \u7e5d\uff61\u7e67\uff64\u7e5d\uff6a\u7e67\uff6a, Meiryo, &quot;\ufffd\uff6d\ufffd\uff73 \ufffd\uff70\u7e67\uff74\u7e67\uff77\u7e5d\ufffd\u3051&quot;, &quot;Hiragino kaku Gothic Pro&quot;, &quot;\u7e5d\u5075\u039b\u7e67\uff6e\u7e5d\u624b\uff67\u5075\u3056 Pro W3&quot;, Osaka, sans-serif; font-size: small; font-weight: 400; line-height: 1.4em; line-break: strict; color: rgb(51, 51, 51); text-shadow: rgb(255, 255, 255) 0px 1px 0px;\"><span style=\"font-style: normal; font-size: small; font-weight: 400;\">\u79c1\u305f\u3061\u306f\u3001\u30d2\u30c8\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\uff08HDF\uff09\u3068\u4e73\u9178\u83cc\uff08LAB\uff09\u306e\u5171\u751f\u95a2\u4fc2\u306b\u8208\u5473\u3092\u6301\u3061\u3001\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\n\n\u57f9\u990a\u6761\u4ef6\u4e0b\u306b\u304a\u3044\u3066\u3001LAB\u3092\u53d6\u308a\u8fbc\u3093\u3060\u7d30\u80de\u306f\u3001\u80da\u6027\u5e79\u7d30\u80de\u69d8\u306e\u7d30\u80de\u30af\u30e9\u30b9\u30bf\u30fc\u3092\u5f62\u6210\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u305d\u306e\u30af\u30e9\u30b9\u30bf\u30fc\u306f\u8907\u6570\u306e\u80da\u8449\u7531\u6765\u306e\u591a\u80fd\u6027\u5e79\u7d30\u80de\u3078\u3068\u5206\u5316\u3057\u307e\u3057\u305f\u3002\n\n\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u89e3\u6790\u306e\u7d50\u679c\u3001\u3053\u306e\u7d30\u80de\u30af\u30e9\u30b9\u30bf\u30fc\u306fHDF\u7d30\u80de\u3088\u308a\u3082\u591a\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u3001\u305d\u308c\u306fNANOG\u306e\u767a\u73fe\u306b\u3088\u3063\u3066\u88cf\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001\u4f53\u306e\u524d\u5f8c\u8ef8\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308bHOX\u907a\u4f1d\u5b50\u30af\u30e9\u30b9\u30bf\u30fc\u306e\u767a\u73fe\u306f\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\uff08Ohta et al., PLOS ONE, 2012\uff09\u3002\n\n\u3053\u308c\u3089\u306e\u73fe\u8c61\u3092\u8e0f\u307e\u3048\u3001\u79c1\u305f\u3061\u306f\u3053\u306e\u591a\u80fd\u6027\u8a98\u5c0e\u306b\u95a2\u308f\u308b\u7d30\u83cc\u7531\u6765\u306e\u56e0\u5b50\u3092\u3055\u3089\u306b\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u305d\u308c\u304c\u30ea\u30dc\u30bd\u30fc\u30e0\u3067\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\n\u30ea\u30dc\u30bd\u30fc\u30e0\u3092\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u305b\u308b\u3053\u3068\u3067\u3001\u4e73\u9178\u83cc\u3068\u540c\u69d8\u306b\u591a\u80fd\u6027\u3092\u8a98\u5c0e\u3067\u304d\u308b\u306e\u3067\u3059\uff08Ito et al., Scientific Reports, 2018\uff09\u3002\n\n\u30ea\u30dc\u30bd\u30fc\u30e0\u306f\u4e00\u822c\u306b\u7ffb\u8a33\u3092\u62c5\u3046\u5206\u5b50\u6a5f\u68b0\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001**moonlighting function\uff08\u526f\u6b21\u7684\u6a5f\u80fd\uff09**\u3082\u6301\u3064\u3053\u3068\u304c\u8fd1\u5e74\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u591a\u80fd\u6027\u8a98\u5c0e\u56e0\u5b50\u3068\u3057\u3066\u306e\u30ea\u30dc\u30bd\u30fc\u30e0\u306e\u50cd\u304d\u304c\u305d\u306e\u4e00\u4f8b\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\n\n\u73fe\u5728\u306f\u3001\u30ea\u30dc\u30bd\u30fc\u30e0\u3092\u4ecb\u3057\u305f\u591a\u80fd\u6027\u7372\u5f97\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002&nbsp;&nbsp;<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e5fdae0\" data-id=\"e5fdae0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bb42d94 elementor-widget elementor-widget-spacer\" data-id=\"bb42d94\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-96b5b53 elementor-widget elementor-widget-image\" data-id=\"96b5b53\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"1772\" src=\"https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/ribosome-project-summary-scaled.jpg\" class=\"attachment-full size-full wp-image-976\" alt=\"\" srcset=\"https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/ribosome-project-summary-scaled.jpg 2560w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/ribosome-project-summary-300x208.jpg 300w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/ribosome-project-summary-1024x709.jpg 1024w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/ribosome-project-summary-768x532.jpg 768w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/ribosome-project-summary-1536x1063.jpg 1536w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/ribosome-project-summary-2048x1418.jpg 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5dc6632 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5dc6632\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-83f042a\" data-id=\"83f042a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-85f218b elementor-widget elementor-widget-heading\" data-id=\"85f218b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 2.5rem;font-style: normal;font-weight: 700\">TSUKUSHI<\/span><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b093b3 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9b093b3\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;none&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 24 24&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M24,8v12H0V8H24z M24,4v1H0V4H24z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f2a8a0 elementor-widget elementor-widget-text-editor\" data-id=\"1f2a8a0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size: small; font-style: normal; font-weight: 400; margin-bottom: 1em; padding: 5px; font-family: \u7e5d\uff61\u7e67\uff64\u7e5d\uff6a\u7e67\uff6a, Meiryo, '\ufffd\uff6d\ufffd\uff73 \ufffd\uff70\u7e67\uff74\u7e67\uff77\u7e5d\ufffd\u3051', 'Hiragino kaku Gothic Pro', '\u7e5d\u5075\u039b\u7e67\uff6e\u7e5d\u624b\uff67\u5075\u3056 Pro W3', Osaka, sans-serif; line-height: 1.4em; line-break: strict; color: #333333; text-shadow: #ffffff 0px 1px 0px;\">Tsukushi(TSK:\u30c4\u30af\u30b7\uff09\u306f\u5f53\u7814\u7a76\u5ba4\u3067\u540c\u5b9a\u3057\u5358\u96e2\u751f\u6210\u3057\u305f\u5206\u6ccc\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u547d\u540d\u3055\u308c\u307e\u3057\u305f\u3002\u30c4\u30af\u30b7\u306e\u7531\u6765\u306f\u3001\u30cb\u30ef\u30c8\u30ea\u521d\u671f\u80da\u306b\u304a\u3051\u308b\u767a\u73fe\u69d8\u5f0f\u304c\u65e5\u672c\u56fa\u6709\u306e\u690d\u7269\u3067\u3042\u308b\u30c4\u30af\u30b7\u306b\u3088\u304f\u4f3c\u3066\u3044\u305f\u3053\u3068\u304b\u3089\u540d\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002TSK\u306f\u30cb\u30ef\u30c8\u30ea\u306e\u521d\u671f\u767a\u751f\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046TGF-\u03b2\u3001Notch\u3001FGF\u306a\u3069\u69d8\u3005\u306a\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u8208\u5473\u6df1\u3044\u56e0\u5b50\u3067\u3001\u6b63\u5e38\u306a\u80da\u767a\u751f\u306b\u5927\u304d\u304f\u8ca2\u732e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059(Ohta et al., 2004; Ohta et al., 2006:Kuriyama et al., 2006)<\/p><p style=\"font-size: small; font-style: normal; font-weight: 400; margin-bottom: 1em; padding: 5px; font-family: \u7e5d\uff61\u7e67\uff64\u7e5d\uff6a\u7e67\uff6a, Meiryo, '\ufffd\uff6d\ufffd\uff73 \ufffd\uff70\u7e67\uff74\u7e67\uff77\u7e5d\ufffd\u3051', 'Hiragino kaku Gothic Pro', '\u7e5d\u5075\u039b\u7e67\uff6e\u7e5d\u624b\uff67\u5075\u3056 Pro W3', Osaka, sans-serif; line-height: 1.4em; line-break: strict; color: #333333; text-shadow: #ffffff 0px 1px 0px;\">TSK\u306f\u30cb\u30ef\u30c8\u30ea\u521d\u671f\u80da\u306e\u773c\u306b\u304a\u3044\u3066\u6bdb\u69d8\u4f53\u3068\u7db2\u819c\u5e79\u7d30\u80de\u306b\u304a\u3044\u3066\u767a\u73fe\u304c\u307f\u3089\u308c\u3001\u773c\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u7db2\u819c\u5e79\u7d30\u80de\u306e\u5897\u6b96\u3068\u5206\u5316\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b(Ohta et al., 2011)\u3002\u3055\u3089\u306b\u30de\u30a6\u30b9\u306e\u8133\u306b\u304a\u3044\u3066\u306f\u3001\u55c5\u7403\u3068\u8133\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u304c\u5b58\u5728\u3059\u308b\u5074\u8133\u5ba4\u3068\u6d77\u99ac\u6b6f\u72b6\u56de\u306b\u304a\u3044\u3066\u767a\u73fe\u3057\u3001\u3055\u3089\u306bTSK\u6b20\u640d\u578b\u30de\u30a6\u30b9\u3067\u306f\u3001\u6c34\u982d\u75c7\u69d8\u306b\u8133\u5ba4\u304c\u62e1\u5927\u3059\u308b\u3002TSK\u306f\u30de\u30a6\u30b9\u306e\u8133\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306b\u795e\u7d4c\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u306e\u5236\u5fa1\u56e0\u5b50\u3068\u3057\u3066\u50cd\u304f\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3000(Ito et al., under the review)\u3002<\/p><p style=\"font-size: small; font-style: normal; font-weight: 400; margin-bottom: 1em; padding: 5px; font-family: \u7e5d\uff61\u7e67\uff64\u7e5d\uff6a\u7e67\uff6a, Meiryo, '\ufffd\uff6d\ufffd\uff73 \ufffd\uff70\u7e67\uff74\u7e67\uff77\u7e5d\ufffd\u3051', 'Hiragino kaku Gothic Pro', '\u7e5d\u5075\u039b\u7e67\uff6e\u7e5d\u624b\uff67\u5075\u3056 Pro W3', Osaka, sans-serif; line-height: 1.4em; line-break: strict; color: #333333; text-shadow: #ffffff 0px 1px 0px;\">TSK\u6b20\u640d\u578b\u30de\u30a6\u30b9\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001TSK\u306f\u795e\u7d4c\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068(Ito et al 2010; Hossain et al 2013)\u3001\u6bdb\u5e79\u7d30\u80de\u306e\u767a\u9054\u3068\u808c\u306e\u5275\u50b7\u6cbb\u7652\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068(zniimori et al 2012)\u3001\u307e\u305f\u3001TSK\u306f\u7d30\u80de\u5916\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3068\u3057\u3066\u3055\u307e\u3056\u307e\u306a\u73fe\u8c61\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u306b\u304a\u3051\u308b\u3055\u307e\u3056\u307e\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-19fa905\" data-id=\"19fa905\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4dbd7f7 elementor-widget elementor-widget-spacer\" data-id=\"4dbd7f7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-627a724 elementor-widget elementor-widget-image\" data-id=\"627a724\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"709\" src=\"https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/06\/tsk-sumr-1024x709.jpg\" class=\"attachment-large size-large wp-image-882\" alt=\"\" srcset=\"https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/06\/tsk-sumr-1024x709.jpg 1024w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/06\/tsk-sumr-300x208.jpg 300w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/06\/tsk-sumr-768x532.jpg 768w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/06\/tsk-sumr-1536x1063.jpg 1536w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/06\/tsk-sumr-2048x1418.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-83419b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"83419b3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-fc86a81\" data-id=\"fc86a81\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-849683f elementor-widget elementor-widget-heading\" data-id=\"849683f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-family: Montserrat, sans-serif;font-size: 2.5rem;font-style: normal;font-weight: 700\">AKHIRIN<\/span><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-68959c2 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"68959c2\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;none&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 24 24&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M24,8v12H0V8H24z M24,4v1H0V4H24z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39a4ada elementor-widget elementor-widget-text-editor\" data-id=\"39a4ada\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size: small; font-style: normal; font-weight: 400; margin-bottom: 1em; padding: 5px; font-family: \u7e5d\uff61\u7e67\uff64\u7e5d\uff6a\u7e67\uff6a, Meiryo, '\ufffd\uff6d\ufffd\uff73 \ufffd\uff70\u7e67\uff74\u7e67\uff77\u7e5d\ufffd\u3051', 'Hiragino kaku Gothic Pro', '\u7e5d\u5075\u039b\u7e67\uff6e\u7e5d\u624b\uff67\u5075\u3056 Pro W3', Osaka, sans-serif; line-height: 1.4em; line-break: strict; color: #333333; text-shadow: #ffffff 0px 1px 0px;\">Akhirin(AKH:\u30a2\u30ad\u30ea\u30f3)\u3082\u3001\u672c\u7814\u7a76\u5ba4\u306b\u3088\u3063\u3066\u30cb\u30ef\u30c8\u30ea\u30ec\u30f3\u30ba\u306e\u521d\u671f\u80da\u304b\u3089\u540c\u5b9a\u3055\u308c\u305f\u5206\u6ccc\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002<\/p><p style=\"font-size: small; font-style: normal; font-weight: 400; margin-bottom: 1em; padding: 5px; font-family: \u7e5d\uff61\u7e67\uff64\u7e5d\uff6a\u7e67\uff6a, Meiryo, '\ufffd\uff6d\ufffd\uff73 \ufffd\uff70\u7e67\uff74\u7e67\uff77\u7e5d\ufffd\u3051', 'Hiragino kaku Gothic Pro', '\u7e5d\u5075\u039b\u7e67\uff6e\u7e5d\u624b\uff67\u5075\u3056 Pro W3', Osaka, sans-serif; line-height: 1.4em; line-break: strict; color: #333333; text-shadow: #ffffff 0px 1px 0px;\">AKH\u306f\u305d\u306e\u69cb\u9020\u4e0a\u306b\u3001LCCL(Limulus factor C, Coch-5b2 and Lgl1)\u30c9\u30e1\u30a4\u30f3\u3068\u4e8c\u3064\u306eVWA\u30c9\u30e1\u30a4\u30f3(vWA\u30c9\u30e1\u30a4\u30f3\u306e\u6b20\u640d\u3067\u8840\u6db2\u51dd\u56fa\u969c\u5bb3\u304c\u73fe\u308c\u308b\u3053\u3068\u304c\u3057\u3089\u308c\u3066\u3044\u307e\u3059\u3002\uff09\u3092\u3082\u3061\u3001\u30d8\u30c6\u30ed\u89aa\u548c\u6027\u306e\u63a5\u7740\u6d3b\u6027\u3092\u793a\u3057\u307e\u3059\u3002\u30cb\u30ef\u30c8\u30ea\u306e\u773c\u306e\u5f62\u6210\u904e\u7a0b\u306b\u304a\u3044\u3066\u7db2\u819c\u3084\u6bdb\u69d8\u5e2f\u8fba\u7e01\u5e2f\u306b\u767a\u73fe\u3057(Ahsan et al 2005)\u3001\u810a\u9ac4\u306b\u304a\u3044\u3066\u3082\u4e2d\u5fc3\u7ba1\u306e\u5468\u308a\u3067\u767a\u73fe\u304c\u307f\u3089\u308c\u3001\u810a\u9ac4\u640d\u50b7\u6642\u306b\u3082\u767a\u73fe\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057(Athary et al 2014)\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u5236\u5fa1\u5206\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p><p style=\"font-size: small; font-style: normal; font-weight: 400; margin-bottom: 1em; padding: 5px; font-family: \u7e5d\uff61\u7e67\uff64\u7e5d\uff6a\u7e67\uff6a, Meiryo, '\ufffd\uff6d\ufffd\uff73 \ufffd\uff70\u7e67\uff74\u7e67\uff77\u7e5d\ufffd\u3051', 'Hiragino kaku Gothic Pro', '\u7e5d\u5075\u039b\u7e67\uff6e\u7e5d\u624b\uff67\u5075\u3056 Pro W3', Osaka, sans-serif; line-height: 1.4em; line-break: strict; color: #333333; text-shadow: #ffffff 0px 1px 0px;\"><span style=\"font-size: small; font-style: normal; font-weight: 400;\">2020\u5e74\u306b\u3001AKH\u304c\u30de\u30a6\u30b9\u306e\u8133\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u306b\u304a\u3044\u3066\u3082\u767a\u73fe\u3057\u3001\u8133\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\uff08Anam et al 2020)\u3002AKH\u306e\u8133\u306e\u795e\u7d4c\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u5236\u5fa1\u306e\u8a73\u3057\u3044\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790\u3092\u73fe\u5728\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8d83e1c\" data-id=\"8d83e1c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-71dfec7 elementor-widget elementor-widget-image\" data-id=\"71dfec7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"709\" src=\"https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/akhirin-summary-1024x709.jpg\" class=\"attachment-large size-large wp-image-963\" alt=\"\" srcset=\"https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/akhirin-summary-1024x709.jpg 1024w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/akhirin-summary-300x208.jpg 300w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/akhirin-summary-768x532.jpg 768w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/akhirin-summary-1536x1063.jpg 1536w, https:\/\/kyushu-stemcellbiology.com\/wp-content\/uploads\/2020\/07\/akhirin-summary-2048x1418.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a278b14 elementor-widget elementor-widget-spacer\" data-id=\"a278b14\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3179061 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3179061\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4254154\" data-id=\"4254154\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3f29069 elementor-widget elementor-widget-spacer\" data-id=\"3f29069\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Research Projects Ribosome Various types of bacteria live together and form an ecosystem in the bowels, which is called enteral flora. Lactic acid bacteria are human health improving bacterium which produce lactic acid by digesting sugar. These bacteria are essential for the efficacy of digestion and dermatitis. They are considered as the \u2018first runner of the modern medicine\u2019 with several other promises yet to be elucidated. Basic information such as the influence on epigenome and cell function of the intestinal epithelium cells by the lactic acid bacterium (LAB) is also hardly studied. We are interested to check the symbiotic relationship between the human dermal fibroblast (HDF) cells and LAB. 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